McVay said "the goal" is for Kupp to play in Week 12 against the Arizona Cardinals and that there's "a real possibility that he would be available." McVay said Kupp was encouraged "based on how it felt today" and the results of the testing done on his ankle.
"I know he's going to do everything in his power [to play]," McVay said. "... It's not something where you're saying he's definitely going to be out for this week, but you want to see the functionality."
The Rams, meanwhile, will get leading rusher Kyren Williams back against the Cardinals, McVay said. Williams, who has 456 yards and seven total touchdowns (six rushing) this season, has been on injured reserve with an ankle injury.
Kupp left the Rams' victory over the Seattle Seahawks on Sunday in the second quarter with an ankle injury. He was on the sideline in the third quarter with his helmet on, but he did not return to the field and was officially ruled out at the start of the fourth quarter.
Given Kupp's history with ankle injuries, the Rams will be careful with him as they determine whether he can play against Arizona, sources told ESPN's Adam Schefter. Kupp ended the 2022 season on injured reserve after leaving a Week 10 loss with a high ankle sprain that required surgery.
Kupp, who missed the first four games of the season with a hamstring injury, has 23 catches for 364 yards and a touchdown in 2023.